Temozolomide (NSC 362856), DNA Alkylator
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Descrição
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.
Temozolomide CAS 85622-93-1 Manufacturers, Suppliers, Factory - Home Sunshine Pharma
Temozolomide - an overview
Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide
Selleck Chemical LLC Temozolomide 25mg 85622-93-1 CCRG81045, NSC 362856,TMZ
Temozolomide, C6H6N6O2
Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide
Temozolomide (CCRG 81045, MB 39831, Methazolastone, NSC 362856, TMZ, CAS Number: 85622-93-1)
Temozolomide (NSC 362856), DNA Alkylator
Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide
Current and future developments in the use of temozolomide for the treatment of brain tumours - The Lancet Oncology
Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
Biomedicines, Free Full-Text
Table 1 from Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.
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