Toxins, Free Full-Text
Por um escritor misterioso
Descrição
L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation of platelet aggregation, hemorrhage, and neutrophil activation. Human neutrophils respond to LAAO by enhancing chemotaxis, and phagocytosis, and releasing reactive oxygen species (ROS) and pro-inflammatory mediators. Exosomes cellular nanovesicles play vital roles in intercellular communication, including immune responses. This study investigates the impact of Calloselasma rhodostoma snake venom-derived LAAO (Cr-LAAO) on human neutrophil exosome release, including activation patterns, exosome formation, and content. Neutrophils isolated from healthy donors were stimulated with Cr-LAAO (100 μg/mL) for 3 h, followed by exosome isolation and analysis. Results show that Cr-LAAO induces the release of exosomes with distinct protein content compared to the negative control. Proteomic analysis reveals proteins related to the regulation of immune responses and blood coagulation. This study uncovers Cr-LAAO’s ability to activate human neutrophils, leading to exosome release and facilitating intercellular communication, offering insights into potential therapeutic approaches for inflammatory and immunological disorders.
Toxic Exposure: The True Story behind the Monsanto Trials and the Search for Justice: Nabhan, Chadi: 9781421445359: : Books
Abgt 100 Get File - Colaboratory
The Ultiamte Guide to Toxin-Free Living
Clean Living: How to Reduce your Toxic Load - Finesse Fitness
Toxic Chemicals in Perfumes - Essential Oils
Free from: The Breakdown
Toxins Free Full-Text The Urgent Need To Develop Novel Strategies For The Diagnosis And Treatment Of Snakebites
Listen Free to Toxin Solution: How Hidden Poisons in the Air, Water, Food, and Products We Use Are Destroying Our Health—and What We Can Do to Fix It by Joseph Pizzorno with
Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation
de
por adulto (o preço varia de acordo com o tamanho do grupo)
