Viruses, Free Full-Text
Por um escritor misterioso
Descrição
The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a tool for infection prevention that is implementable alongside vaccination programmes. Nafamostat is a serine protease inhibitor that inhibits SARS-CoV-2 entry in vitro, but it has not been characterised for chemoprophylaxis in animal models. Clinically, nafamostat is limited to intravenous delivery and has an extremely short plasma half-life. This study sought to determine whether intranasal dosing of nafamostat at 5 mg/kg twice daily was able to prevent the airborne transmission of SARS-CoV-2 from infected to uninfected Syrian Golden hamsters. SARS-CoV-2 RNA was detectable in the throat swabs of the water-treated control group 4 days after cohabitation with a SARS-CoV-2 inoculated hamster. However, throat swabs from the intranasal nafamostat-treated hamsters remained SARS-CoV-2 RNA negative for the full 4 days of cohabitation. Significantly lower SARS-CoV-2 RNA concentrations were seen in the nasal turbinates of the nafamostat-treated group compared to the control (p = 0.001). A plaque assay quantified a significantly lower concentration of infectious SARS-CoV-2 in the lungs of the nafamostat-treated group compared to the control (p = 0.035). When taken collectively with the pathological changes observed in the lungs and nasal mucosa, these data are strongly supportive of the utility of intranasally delivered nafamostat for the prevention of SARS-CoV-2 infection.
Panda Free Antivirus Review
virusfree
Molecular characterization of a new virus species identified in yam (Dioscorea spp.) by high-throughput sequencing
The Top 10 Worst Computer Viruses in History
Page 29 Chest Virus Images - Free Download on Freepik
AVG Antivirus Protection & Internet Security Pricing in 2023
Reactivity of Enveloped Virus Genome, Proteins, and Lipids with Free Chlorine and UV254
Virus & threat protection in Windows Security - Microsoft Support
Hp Vca 7.4 Download - Colaboratory
Antibodies, viruses and vaccines
Free Entry Virus - Colaboratory
Avira Free Security Review
How to Remove Virus in a Computer 2023, 2040
Avast, Download Free Antivirus & VPN
de
por adulto (o preço varia de acordo com o tamanho do grupo)